ANSWER: REED Syndrome Test Question

The correct answer is D. Renal 

Correct Answer Explanation

This photo depicts leiomyomas. They are smooth muscle tumors that present with tan to skin-colored papules/nodules. They may be agminated or arranged in a parallel array. Leiomyomas occur in familial multiple cutaneous Leiomyomatosis (Reed Syndrome). It is an autosomal dominant condition due to a defect in fumarate hydratase. It presents with multiple cutaneous leiomyomas, uterine leiomyomas/leiomyosarcoma, and type II papillary renal cell carcinoma.

Incorrect Answer Explanation

Gastric cancer can occur in association with acanthosis nigricans or Leser-Trelat.

Lung cancer can occur in association with erythema gyratum repens or granuloma annulare.

Breast cancer can occur in Cowden syndrome.

Colon cancer can occur in Peutz-Jegher’s syndrome.


Hurwitz S. Clinical Pediatric Dermatology, 2nd ed. Philadelphia: W. B. Saunders; 1990.