Pop Quiz Answer #27 – 10/5


Correct Answer: D. Muscle spasms



Vismodegib is smoothened (SMO) inhibitor approved for the treatment of adults with basal cell nevus syndrome, metastatic or locally advanced BCC that has recurred following surgery or who are not candidates for surgery or radiation. The most commonly reported side effect is muscle spasm, followed by alopecia and dysgeusia.

Reference: Sekulic A et al. Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma. N Engl J Med. 2012;366:2171-79


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