Friday Pop Quiz #19 – 5/10

Photomediated Reaction

Answer: A. Demeclocycline

The tetracycline family of antibiotics are bacteriostatic and act by inhibiting protein synthesis. Each member of the family may cause photosensitivity, but demeclocycline is the most photosensitizing. The pathogenesis of phototoxicity involves the generation of free oxygen radicals, superoxide anions, hydroxyl radicals and singlet oxygen, which leads to a host of cytotoxic tissue effects. Other mechanisms of damage include the generation of stable photoproducts (e.g. chlorpromazine, tetracyclines), the formation of photoadducts (e.g. psoralens), and the recruitment of inflammatory mediators (e.g. porphyrins, demeclocycline).

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