Utility of Pulsed-Dye Laser in the Treatment of Recalcitrant Hailey-Hailey Disease
204152041520415Hailey-Hailey Disease INTRODUCTION Benign Familial Pemphigus, or Hailey-Hailey Disease (HHD), affects intertriginous areas of the skin causing epidermal blistering and vesicles that coalesce into weeping and crusting plaques.¹ The loss-of-function mutation of the ATP2C1 gene causes a disruption in calcium homeostasis of keratinocytes. The resulting dysfunction in desmosomes and cell-cell adhesion causes acanthol …
Hailey-Hailey Disease
Tirbanibulin Therapeutic Cheat Sheet
204082040820408TirbanibulinCurrent field-directed treatments of actinic keratosis (AK), a pre-malignant condition, are often limited by severe local reactions and/or complex treatment. Tirbanibulin, a novel potent anti-proliferative synthetic agent that inhibits tubulin polymerization and Src kinase signalling, offers a convenient, safe, and effective field treatment of actinic keratosis. We continue our surgical Therapeut …
Tirbanibulin
Using Superficial Chemical Peels to Treat Pigmentary Disorders
203932039320393superficial chemical peelsNext Steps in Derm, in partnership with Pigmentary Disorders Exchange Symposium, interviewed Dr. Heather Woolery-Lloyd, director of the Skin of Color Division for the University of Miami Department of Dermatology. Watch as Dr. Woolery-Lloyd outlines the role of superficial chemical peels in treating pigmentary disorders. Learn how chemical peels impact other treatments. Find out her chemical peel …
superficial chemical peels
Fluconazole Therapeutic Cheat Sheet
203852038520385fluconazoleFluconazole is a synthetic triazole with a broader antifungal spectrum than the imidazole class. Resistance to first-pass metabolism and consistent oral absorption are advantages over agents like ketoconazole in the antifungal armamentarium, particularly in the context of the United States Food and Drug Administration’s reinforced warning against oral ketoconazole for skin and nail infections, d …
fluconazole
Author Q&A: YouTube Videos on Topical Steroid Withdrawal
203812038120381topical steroid withdrawalThe 10 most viewed YouTube videos on topical steroid withdrawal (TSW) overall had low reliability and quality, according to a study published in the November issue of the Journal of Drugs in Dermatology. The authors recommend dermatologists provide alternate, evidence-based resources for their patients, both in clinical practice and online, including YouTube. To find out more about the quality …
topical steroid withdrawal