The Happy Face Treatment
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Introduction
When viewing the most famous smiles in history (Figure 1), two constants become apparent: a smooth perioral surface and oral commissures that are turned upward (or horizontal as a minimum). Patients are often fixated on improving both the marionette lines and the downward oral commissures as these distractions are one of the most noticeable areas in the aging face to the average pers …
Introduction
When viewing the most famous smiles in history (Figure 1), two constants become apparent: a smooth perioral surface and oral commissures that are turned upward (or horizontal as a minimum). Patients are often fixated on improving both the marionette lines and the downward oral commissures as these distractions are one of the most noticeable areas in the aging face to the average pers … 
The end of residency is a major milestone. One intern year and three years of dermatology later, we are ready for the next step. Some of us start fellowships, while others start practicing as fully-fledged dermatologists. Many of us move to new cities. And all of us start cramming for the board certification exam, which is only weeks away after our final day of residency.
We are starting our ne … 
The patient had an extensive superficial basal cell carcinoma on the forehead treated with topical imiquimod and returned 4-weeks later with this reaction. Which cytokine is not activated by this medication?
A. Tumor necrosis factor (TNF)-α
B. Interferon (IFN)-α
C. Interferon (IFN)-γ
D. Interleukin (IL)-12
E. Interleukin (IL)-4
To find out the correct answer and read the explanation … 
Below are the issue highlights and Editor Picks for the January issue of JDD!
Final Data From the Condition of Submental Fullness and Treatment Outcomes Registry (CONTOUR) provides insights into the treatment of submental fat in clinical practice.
Tretinoin 0.05% lotion provides an alternative solution in Novel Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate-to-Severe Acne … 
An ancient Chinese theory of acne is gaining popularity in the consumer media. Acne face mapping is the idea that the placement of acne breakouts on the skin reveal the location of health issues occurring inside the body. Consumer lifestyle website Refinery29 wrote an article recently about acne face mapping, which claimed acne in certain locations as signs of imbalances in the digestive system … 