Calciphylaxis – Friday Pop Quiz 5/21
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A 65-year-old female patient presents with poorly demarcated, symmetric, very painful patches of erythema and retiform purpura, favoring the thighs and buttocks. Bullae and a dusky gray discoloration developed, as well as the appearance of ulcerations with black, leathery eschars. A skin biopsy of the affected area is suggestive of calciphylaxis. Shortly after, she dies from secondary infectio …
A 65-year-old female patient presents with poorly demarcated, symmetric, very painful patches of erythema and retiform purpura, favoring the thighs and buttocks. Bullae and a dusky gray discoloration developed, as well as the appearance of ulcerations with black, leathery eschars. A skin biopsy of the affected area is suggestive of calciphylaxis. Shortly after, she dies from secondary infectio … 
This tumor commonly results from mutations in p53. Which of the following is correct?
A. It is the most common type of skin cancer in Caucasians
B. Oral variants most commonly present on the dorsal tongue
C. It is typically less aggressive in patients with CLL
D. plant patients have a 10-fold increased risk of developing this tumor
E. Tumors arising within scars/chronic ulcers h … 
A biopsy for DIF is negative. IIF is positive for IgG antibodies directed against monkey esophagus. Which of the following is true regarding the diagnosis?
A. The primary target antigen is desmoglein 1
B. A positive DIF would show intercellular and linear IgG & C3 along the BMZ
C. It is associated with bronchiolitis obliterans
D. Autoantibody titers correlate with disease activ … 
Which subtype of this disease is most common in the United States?
A. C
B. A
C. B
D. D
E. E
To find out the correct answer and read the explanation, click here.
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On this Mnemonic Monday, we challenge you to remember the list of subepidermal and pauci-inflammatory disorders in dermatopathology:
Porphyria cutanea tarda (PCT)
Epidermolysis bullousa acquisita (EBA)
Toxic epidermal necrolysis/Stevens-Johnson syndrome (TEN/SJS)
Bullous pemphigoid
Cicatricial pemphigoid
Dermatitis herpetiformis
Bullous lupus erythematosus (think “SLE”)
Linear IgA bu … 