Severe Oral Mucositis: A Rare Adverse Event of Pembrolizumab
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Treatment of malignancy with anti-programmed cell death 1 (PD-1) immune checkpoint inhibitors can cause mucocutaneous side effects resulting from T cell activation. Due to their recent development, the full side effect profile remains to be fully elucidated, however dermatologic adverse events are most common. The main oral toxicities of these immune checkpoint inhibitors include: xerostomia, dysg …
Treatment of malignancy with anti-programmed cell death 1 (PD-1) immune checkpoint inhibitors can cause mucocutaneous side effects resulting from T cell activation. Due to their recent development, the full side effect profile remains to be fully elucidated, however dermatologic adverse events are most common. The main oral toxicities of these immune checkpoint inhibitors include: xerostomia, dysg … Continue reading "Severe Oral Mucositis: A Rare Adverse Event of Pembrolizumab"
While I was beginning the process of “scrubbing in” to assist in the hemicolectomy case as an intern, I carefully squeezed the anti-septic chlorhexidine-soaked sponge and watched the brown solution drip its way down my forearms. I continued the ritual by cleaning under the fingernails and on every plane of the fingers, hands, and forearms multiple times. After all; “Clean Hands Save Lives,� … 
The February issue of the Journal of Drugs in Dermatology features an outstanding line-up of articles with topics ranging from acne and depression to "Inflammaging. Straight from the JDD Editor’s desk, we share this month’s issue highlights:
Efforts are needed to implement a clinically useful definition of moderate plaque psoriasis in Dermatologists’ Perspectives on Defining Moderate Ps … 
Malignant proliferating trichilemmal tumors are rare adnexal neoplasms that most commonly occur on the scalp in elderly women. These tumors are associated with recurrence and even nodal or distant metastatic spread. Here, JDD authors describe a 38-year-old patient who presented with a scalp nodule that was diagnosed as a high-grade malignant proliferating trichilemmal tumor.
Introduction
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CASE REPORT
A 71-year-old Fitzpatrick phototype IV man with a history of hyperlipidemia and extensive travel to the Middle East presented with a mildly painful vegetative growth on his right lower leg for 1.5 months (Figure 1). In 2014, the patient reported a pruritic “rash” in the same location, which was treated with fluocinonide .05% ointment with resolution.
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