Widespread Skin Necrosis Secondary to Gemcitabine Therapy
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INTRODUCTION
Cutaneous side effects are relatively common in chemotherapy but vary in frequency and severity depending on the medication, dose, duration, pharmacokinetics, and pharmacodynamics. Gemcitabine, a pyrimidine nucleoside analogue, is a common oncologic agent used in the treatment of a variety of malignancies such as cancers of the head and neck, lung cancer, breast cancer, pancreatic …
INTRODUCTION
Cutaneous side effects are relatively common in chemotherapy but vary in frequency and severity depending on the medication, dose, duration, pharmacokinetics, and pharmacodynamics. Gemcitabine, a pyrimidine nucleoside analogue, is a common oncologic agent used in the treatment of a variety of malignancies such as cancers of the head and neck, lung cancer, breast cancer, pancreatic … Continue reading "Widespread Skin Necrosis Secondary to Gemcitabine Therapy"
INTRODUCTION
Erosive pustular dermatosis (EPD) is a rare inflammatory skin disorder typically of the scalp in older patients characterized by crusted erosions, sterile pustules, skin atrophy, and scarring alopecia.1-3 However, few cases of leg involvement have been reported.4 EPD of the leg (EPDL) has been associated with venous leg ulcers (VLUs), venous insufficiency, and skin atrophy.1,5,6 It … 
CASE
A 47-year-old woman presented for Mohs Micrographic Surgery for a biopsy-proven basal cell carcinoma involving the right nasal ala. The patient had a history of basal cell nevus syndrome (BCNS) and previous history of multiple basal cell carcinomas.
On initial examination, the patient was noted to have a few scattered pearly molluscoid papules on the head and neck, which were suspicio … 
Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia that is currently regarded as a variant of lichen planopilaris. FFA has historically been considered rare in black patients, in whom traction alopecia, central centrifugal cicatricial alopecia, and androgenetic alopecia are frequently assumed to be more common. JDD author Kimberly Huerth, MD, ME describes a case of FFA … 
JDD Authors Rachel Fayne BA, Sonali Nanda MS, Anna Nichols MD PhD, and John Shen MD report a case of biopsy-proven invasive SCC in an 86-year-old Caucasian male with history of multiple actinic keratoses and no previous skin cancers. The patient declined surgical treatment due to concerns about cosmetic outcomes. A combination of topical 5% imiquimod cream, 2% 5-FU solution, and 0.1% tretinoin cre … 