Severe Psoriasis Presenting in 3-Year-Old Child With Nail Dystrophy: Response to Biologic Treatment
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Psoriasis, a chronic inflammatory skin condition, affects about 2% of children. A small subset have isolated nail involvement refractory to topical treatment that can be disabling. The development of targeted biologic agents offers safe, effective options for children with moderate-to-severe skin and nail disease. A few are now Food and Drug Administration (FDA)-approved for children.
INTRODUCTIO …
Psoriasis, a chronic inflammatory skin condition, affects about 2% of children. A small subset have isolated nail involvement refractory to topical treatment that can be disabling. The development of targeted biologic agents offers safe, effective options for children with moderate-to-severe skin and nail disease. A few are now Food and Drug Administration (FDA)-approved for children.
INTRODUCTIO … 
Before we dive into our discussion, let’s outline the Guideline-Based Approach to Treatment Selection.
The International Psoriasis Council has divided psoriasis treatment classification into 2 groups:
Patients who are a candidate for topical therapy, or
Patients who are a candidate for systemic therapy
Candidates for systemic therapy must meet at least 1 of the following … 
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Psoriasis involves a complex inflammatory cascade mediated by various cytokine effectors. Over the past fifteen years, treatment options have evolved to include biologic medications that provide targeted inhibition of various pathways. IL-23 has emerged as an important inflammatory cytokine in the pathogenesis of psoriasis. We continue our series, Therapeutic Cheat Sheet, with a closer look at IL- … 