A 14-year-old female presents with the sudden onset of the skin findings pictured diffusely covering greater than 90% of her skin surface. The rash is accompanied by a high fever (40C) and elevated white blood cell count. What is the most likely cause of her condition?

A. ABCC6 mutation

B. Anti-FceR1 IgG antibodies

C. Anti-transglutaminase 3 antibodies

D. Deficiency of the IL-36 receptor antagonist

E. SPINK5 mutation

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