Derm Topics

Cutaneous Signs of Systemic Disease | Pearls from the Expert

Next Steps in Derm and the Journal of Drugs in Dermatology, in partnership with the Dermatology Education Foundation (DEF) and Physicians Resources,  interviewed board-certified dermatologist and dermatologic surgeon Dr. Brad Glick on his approach to patients with cutaneous signs of systemic disease.

Watch as he shares many examples of common and less common systemic diseases with  dermatological manifestations, what to look for, and the importance of taking a step back and looking at the whole picture. He reminds dermatology clinicians that  “what you may be seeing in the skin may represent something that is going on much deeper”. A pearl-packed video you can’t miss!

Dr. Brad Glick lectured on this and other topics at the recent  DERM2O22 NP/PA CME conference held July 28-31, 2022.

Further Reading

If you want to read more about systemic diseases with skin manifestations, check out the following article and case report published in the Journal of Drugs in Dermatology (JDD).

Efficacy and Safety of Systemic Treatments for Skin and Joint Manifestations in Patients With Psoriasis


Psoriasis is a chronic, systemic disease with features suggestive of autoimmune dysregulation. Patients with psoriasis vulgaris frequently experience systemic comorbidities, including cardiovascular and metabolic diseases, and approximately 30% develop psoriatic arthritis (PsA), which requires treatment. It is important that physicians and patients are aware of the breadth of treatment options available to treat the complete spectrum of psoriasis manifestations. This narrative review summarizes clinical information from approved systemic psoriasis therapies relevant to the treatment of PsA and related systemic pathologies. We include pivotal clinical trials of biologic therapies that are approved by the US Food and Drug Administration for psoriasis and PsA and additional studies identified from PubMed and congress abstract searches through August 21, 2019. We comment on the real-world effectiveness of traditional nonbiologic treatment options, including methotrexate, cyclosporine, acitretin, systemic corticosteroids, and nonsteroidal anti-inflammatory drugs and consider targeted synthetic and biologic disease-modifying antirheumatic drugs and their efficacy and safety in treating skin and joint manifestations. Finally, we discuss key considerations when managing patients with PsA as a comorbidity of psoriasis. The individual treatment needs of patients should be met while psoriasis and its systemic complications are managed. When addressing these needs, it is important to consider modern biologics and other systemic therapies. Read the full article here.

J Drugs Dermatol. 2020;19(3): doi:10.36849/JDD.2020.4690

Cutaneous Lupus Erythematosus in a Patient Undergoing Intravitreal Bevacizumab Injections: Case Report and Review of the Literature


INTRODUCTION: Bevacizumab is a recombinant humanized antibody against vascular endothelial growth factor (VEGF). It is approved by the Food and Drug Administration (FDA) for metastatic colorectal cancer, advanced non-small cell lung cancer, metastatic renal cell cancer and glioblastoma. Bevacizumab has also been used off label in ophthalmology for age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, retinopathy of prematurity, and other chorioretinal vascular disorders. Numerous case reports have described various cutaneous reactions in response to bevacizumab therapy including acneiform eruptions and exfoliative dermatitis.
CASE PRESENTATION: We report a case of a 63 year-old Caucasian female who presented with subacute cutaneous lupus erythematosus six weeks after initiating two intravitreal injections of bevacizumab for central serous choroidopathy.
CONCLUSION: We report the first documented case of a cutaneous lupus erythematosus eruption following bevacizumab administration as a monotherapy. Read the full case report here.

J Drugs Dermatol. 2013;12(9):1052-1055.

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