JDD Corner

JDD February 2023 Issue Highlights

The February issue of the Journal of Drugs in Dermatology (JDD) includes the perfect blend of original articles, case reports, and brief communications exploring topics such as efficacy and safety of 1% clascoterone cream in patients aged ≥12 years with acne vulgaris, dupilumab’s impact on atopic dermatitis among adolescent and adult patients, development and validation of a photonumeric scale for the evaluation of jawline contour, PDT and actinic keratoses, and many more.  Check out this month’s issue highlights straight from the JDD Editor’s desk:

In Burden, Control, and Treatment of Moderate to Severe Atopic Dermatitis in 2021: A United States Patient Survey Studyresults suggest a need for additional education on current and new therapies.

Meeting Patient Expectations of Topical Psoriasis Treatment: Evidence Supporting the Use of Fixed-Combination Halobetasol/Tazarotene Lotion shows that this option has a favorable safety profile with low rates of irritation and local skin reactions in clinical studies.

Results support additional larger clinical trials to assess its potential as a once-daily, nonsteroidal topical AD treatment in The Safety and Efficacy of Roflumilast Cream 0.15% and 0.05% in Patients With Atopic Dermatitis: Randomized, Double-Blind, Phase 2 Proof of Concept Study.

Interviews are conducted with participants who received a diagnosis between 2017 and 2022 in A Qualitative Study on Dupilumab’s Impact on Atopic Dermatitis Among Adolescent and Adult Patients.

The National Eczema Association (NEA) administers a 25-question online survey to NEA members in Atopic Dermatitis Polypharmacy and Out-Of-Pocket Healthcare Expenses. 

Treatment assignment is performed using a central interactive web response system by a computer-generated randomization schedule in Efficacy and Safety of Calcipotriene/Betamethasone Dipropionate Foam in the Treatment of Psoriasis in Skin of Color.

In Efficacy and Safety of 1% Clascoterone Cream in Patients Aged ≥12 Years With Acne Vulgaris, treatment-emergent adverse events (TEAEs) and local skin reactions (LSRs; edema, erythema/redness, pruritus, scaling/dryness, skin atrophy, stinging/burning, striae rubrae, and telangiectasia) are assessed at each study visit. 

In Molluscum Contagiosum Virus Evasion of Immune Surveillance: A Review, authors compile original research articles and identify 11 proteins produced by MCV that are postulated to participate in the evasion of host immunity through various molecular pathways.

Concordance in Distinguishing Actinic Keratosis From Squamous Cell Carcinoma in Situ on Mohs Histological Frozen Sections argues that ongoing learning and consensus building among surgeons and trainees can aid in quality patient care, even if there may not be agreement on every case.

Online Health Information for Acne Keloidalis Nuchae Has a Difficult Level of Readability determines that this evaluation is important for improving both patient understanding and population-wide health equity.

Subjects enrolled in this single-center, randomized, vehicle, and comparator-controlled clinical trial and treated once daily over 12 days (10 applications) in Efficacy and Safety of Water-Free Lipid Formulation System Containing Calcipotriol Against Psoriasis Vulgaris.

The objective of the Development and Validation of a Photonumeric Scale for the Evaluation of Jawline Contour is to present scale-development methods for the Jawline Assessment Scale and establish its reliability.

Graham-Little-Piccardi-Lasseur Syndrome: A Case Report examines a patient with GLPLS, discusses pertinent morphologic and dermoscopic findings, and reviews the current literature.

In Pigmented Basal Cell Carcinoma: An Argument for Sub-Classification, the authors assert that implementation of this system requires improved physician education and research.

Differential RNA Transcriptome in Ustekinumab Responders vs Non-Responders utilizes a similar whole blood transcriptome analysis to investigate the intersection of psoriasis endotypes and treatment response.

An Investigator-Initiated Trial of a Polymeric Emulsion of Halobetasol Propionate and Tazarotene in the Treatment of Palmoplantar Psoriasis studies patients with this chronic, difficult-to-treat localized variant that affects the palms and soles.

Shining Light on PDT and Actinic Keratoses proposes that in patients with known contraindications to photosensitizing agents, this could be an effective way to clear AKs while avoiding the harmful side effects of photosensitizing agents.

Practical Approaches to the Diagnosis and Management of Sensitive Skin: A Scoping Review states that management is highly personalized and relies on strong patient-physician partnership and a high level of patient involvement to achieve relief of symptoms, optimize skincare, and identify triggers.

Find more JDD Issue Highlights here